December 28, 2018

Chemical Strategies for Improving Islet Transplant Outcomes

Quintana, J., Stinchcomb, A., Kostyo, J., Robichaud, B., Plunk, M., & Kane, R. (2018). “Chemical Strategies for Improving Islet Transplant Outcomes” OBM Transplantation 2018, 2(4), 1-1.

Abstract: Islet transplantation has proven to be a viable treatment for individuals suffering from both Type 1 Diabetes Mellitus (T1D) and chronic pancreatitis. However, a variety of challenges limit the effectiveness of this procedure by reducing the number of islets that survive the harvesting and transplantation processes. Increasing islet survival would increase the long-term effectiveness of the procedure and allow this technique to be used in more patients. A number of factors have been shown to improve the outcomes of pancreatic islet transplantation, including immunological suppression and prevention of coagulation. In this review, we will discuss various chemical strategies reported in the literature for the preservation of islet graft function after transplantation, including islet encapsulation, the adoption of anti-inflammatory and immune suppressing molecules, and islet surface modification.

Related Team:

Jessica Kostyo

Technical Advisor