May 9, 2016

Interaction of BODIPY Dyes with Bovine Serum Albumin: A Case Study on the Aggregation of a Click-BODIPY Dye

L.P. Jameson, et al., “Interaction of BODIPY Dyes with Bovine Serum Albumin: A Case Study on the Aggregation of a Click-BODIPY Dye,” Phys. Chem. Chem. Phys., 2016, 18, 14182-14185
(Laramie P. Jameson, Nicholas W. Smith, Onofrio Annunziata and Sergei V. Dzyuba)

Abstract: The fluorescence of BODIPY and click-BODIPY dyes was found to substantially increase in the presence of bovine serum albumin (BSA). BSA acted as a solubilizer for dye aggregates, in addition to being a conventional binding scaffold for the click-BODIPY dyes, indicating that disaggregation of fluorophores should be considered when evaluating dye–protein interactions.


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Nicholas Smith, Ph.D.

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